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Symbol
Name
ID

Aire
autoimmune regulator
MGI:1338803

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Type I diabetes mellitus	Decreased circulating parathyroid hormone level	Adrenal insufficiency	Primary adrenal insufficiency	Decreased circulating aldosterone level	Hypoparathyroidism	Hypothyroidism	Female hypogonadism	Male hypogonadism
Disease(s) Associated with AIRE
autoimmune polyendocrine syndrome type 1

Mouse Phenotypes

parotid gland inflammation

sublingual gland inflammation

submandibular gland inflammation

salivary gland inflammation

endocrine/exocrine gland phenotype

absent adrenal gland

abnormal thymus morphology

absent Hassall's corpuscle

abnormal thymus medulla morphology

thymus atrophy

abnormal thymus physiology

thyroid gland inflammation

lacrimal gland inflammation

prostate gland inflammation

pancreas inflammation

chronic pancreas inflammation

insulitis

ovary inflammation

Availability

Mouse Genotype

Aire^tm1.1Doi/Aire^tm1.1Doi

!

!

!

!

!

Aire^tm1Mand/Aire^tm1Mand

Aire^tm1Mmat/Aire^tm1Mmat

*

Aire^tm1Pltn/Aire^tm1Pltn

Aire^tm1Ptsn/Aire^tm1Ptsn

Aire^tm2Mmat/Aire^tm2Mmat

Aire^tm1Mand/Aire⁺

Aire^tm1Mand/Aire^tm1.1Doi

Aire^tm1Mmat/Aire^tm2Mmat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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